Molecular systematics and phylogeography of the Helmeted Guineafowl (Numida meleagris)

Includes bibliographical references (leaves 61-67)

Phylogeograpy of Aphanicercella cassida (Plecoptera : Notonemourida) : cryptic speciation?

Stoneflies (Plecoptera) in South Africa are limited to cool pristine mountain streams. This provides them with very limited habitat in which to survive. The species of stonefly studied in this project (Aphanicercella cassida) has a very wide distribution unlike most other species which have a limited range. Of particular interest is a population in Mpumalanga (north of South Africa) which is very disjunct from the other populations of A. cassida found widely in the southwestern Cape. Despite this large geographic distance the insects appear to be morphologically identical to one another. It is believed that there is limited or no gene flow between the northern and southern populations as stoneflies are poor fliers. Molecular analysis of the cytochrome oxidase I gene in the mitochondrial DNA was analysed to see if any genetic differentiation was occurring inspite of the morphological homogeneity. A 557 base pair region was compared across three populations of A. cassida one in Mpumalanga and two in the southwestern Cape. Two congeneric species, A. bullata and A. scutata, were used as outgroups. The findings of this study were quite dramatic. The northern population is extremely different from the southern populations at the molecular level. There is more variation between the two populations of A. cassida than between the two outgroup species and the split between the two disjunct populations displays evidence of an ancient vicariance event. This finding definitely warrants further investigation into whether the population of A. cassida in Mpumalanga is a cryptic species. More sampling has to be done within the studied populations and more populations should be added to the analysis before any definite decision can be made regarding this fascinating emergence of possible cryptic species in South African stoneflies

Habitable Exoplanet Imager Optical-Mechanical Design and Analysis

The Habitable Exoplanet Imager (HabEx) is a space telescope currently in development whose mission includes finding and spectroscopically characterizing exoplanets. Effective high-contrast imaging requires tight stability requirements of the mirrors to prevent issues such as line of sight and wavefront errors. PATRAN and NASTRAN were used to model updates in the design of the HabEx telescope and find how those updates affected stability. Most of the structural modifications increased first mode frequencies and improved line of sight errors. These studies will be used to help define the baseline HabEx telescope design

Marine baseline and monitoring strategies for Carbon Dioxide Capture and Storage (CCS)

The QICS controlled release experiment demonstrates that leaks of carbon dioxide (CO2) gas can be detected by monitoring acoustic, geochemical and biological parameters within a given marine system. However the natural complexity and variability of marine system responses to (artificial) leakage strongly suggests that there are no absolute indicators of leakage or impact that can unequivocally and universally be used for all potential future storage sites. We suggest a multivariate, hierarchical approach to monitoring, escalating from anomaly detection to attribution, quantification and then impact assessment, as required. Given the spatial heterogeneity of many marine ecosystems it is essential that environmental monitoring programmes are supported by a temporally (tidal, seasonal and annual) and spatially resolved baseline of data from which changes can be accurately identified. In this paper we outline and discuss the options for monitoring methodologies and identify the components of an appropriate baseline survey

Combating Youth Unemployment: Developing an Australian Work Readiness Tool

One major cause of youth unemployment globally is a disconnect between the skills youth possess and those required by employers. This project assisted the Brotherhood of St Laurence in combating this skills gap through developing a digital work readiness skills tool. We produced a website for youth to assess their skills, visualize their growth, and match their skill set to different industries. At the close of our project we made recommendations for future developments of the tool and BSL programs

Landscape of IoT security

The last two decades have experienced a steady rise in the production and deployment of sensing-and-connectivity-enabled electronic devices, replacing “regular” physical objects. The resulting Internet-of-Things (IoT) will soon become indispensable for many application domains. Smart objects are continuously being integrated within factories, cities, buildings, health institutions, and private homes. Approximately 30 years after the birth of IoT, society is confronted with significant challenges regarding IoT security. Due to the interconnectivity and ubiquitous use of IoT devices, cyberattacks have widespread impacts on multiple stakeholders. Past events show that the IoT domain holds various vulnerabilities, exploited to generate physical, economic, and health damage. Despite many of these threats, manufacturers struggle to secure IoT devices properly. Thus, this work overviews the IoT security landscape with the intention to emphasize the demand for secured IoT-related products and applications. Therefore, (a) a list of key challenges of securing IoT devices is determined by examining their particular characteristics, (b) major security objectives for secured IoT systems are defined, (c) a threat taxonomy is introduced, which outlines potential security gaps prevalent in current IoT systems, and (d) key countermeasures against the aforementioned threats are summarized for selected IoT security-related technologies available on the market

The Default-Mode Network Represents Aesthetic Appeal that Generalizes Across Visual Domains

Visual aesthetic evaluations, which impact decision-making and well-being, recruit the ventral visual pathway, subcortical reward circuitry, and parts of the medial prefrontal cortex overlapping with the default-mode network (DMN). However, it is unknown whether these networks represent aesthetic appeal in a domain-general fashion, independent of domain-specific representations of stimulus content (artworks versus architecture or natural landscapes). Using a classification approach, we tested whether the DMN or ventral occipitotemporal cortex (VOT) contains a domain-general representation of aesthetic appeal. Classifiers were trained on multivoxel functional MRI response patterns collected while observers made aesthetic judgments about images from one aesthetic domain. Classifier performance (high vs. low aesthetic appeal) was then tested on response patterns from held-out trials from the same domain to derive a measure of domain-specific coding, or from a different domain to derive a measure of domain-general coding. Activity patterns in category-selective VOT contained a degree of domain-specific information about aesthetic appeal, but did not generalize across domains. Activity patterns from the DMN, however, were predictive of aesthetic appeal across domains. Importantly, the ability to predict aesthetic appeal varied systematically; predictions were better for observers who gave more extreme ratings to images subsequently labeled as high or low. These findings support a model of aesthetic appreciation whereby domain-specific representations of the content of visual experiences in VOT feed in to a core domain-general representation of visual aesthetic appeal in the DMN. Whole-brain searchlight analyses identified additional prefrontal regions containing information relevant for appreciation of cultural artifacts (artwork and architecture) but not landscapes

Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

OBJECTIVES: The ALIGN study (NCT01061723) evaluated the efficacy and safety of sarilumab, the first fully human monoclonal antibody against interleukin-6 receptor-alpha (IL-6Ralpha), in patients with ankylosing spondylitis (AS). METHODS: Patients with active AS despite conventional treatment were randomised to placebo, or one of five subcutaneous dose regimens of sarilumab (100, 150 or 200 mg every other week, or 100 or 150 mg every week), for 12 weeks. The primary efficacy end point was the percentage of patients achieving the Axial SpondyloArthritis international Society (ASAS) 20 response criteria at week 12. Secondary endpoints included ASAS40 response, ASAS partial remission, AS Disease Activity Score, high-sensitivity C-reactive protein (hs-CRP) value, and safety. RESULTS: Baseline demographic and disease characteristics of the 301 patients enrolled were similar across treatment groups. At week 12, there was no statistically significant difference in ASAS20 response rate between placebo (ASAS20 = 24.0%) and any sarilumab dose group. A significantly greater reduction in hs-CRP value was achieved with the higher sarilumab doses versus placebo. No other statistically significant differences were evident for secondary efficacy endpoints.The most common treatment-emergent adverse events reported for sarilumab included infections (non-serious), neutropenia, and increase in alanine aminotransferase. No cases of tuberculosis, opportunistic, or fungal infections, or bowel perforations were reported. Seven patients experienced a treatment-emergent serious adverse event (all in sarilumab treatment groups). No deaths occurred. CONCLUSIONS: The ALIGN study shows that IL-6Ralpha blockade with sarilumab was not an effective treatment for AS. Sarilumab was generally well tolerated with a manageable safety profile

Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P\u3c1×10−4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (GWS, p \u3c 5×10−8) in the discovery GWAS were not GWS in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis 30 loci were GWS including 20 novel loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene-sets including regulation of insulin secretion and endocannabinoid signaling. BDI is strongly genetically correlated with schizophrenia, driven by psychosis, whereas BDII is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential new biological mechanisms for BD

Does self-monitoring reduce blood pressure? Meta-analysis with meta-regression of randomized controlled trials

Introduction. Self-monitoring of blood pressure (BP) is an increasingly common part of hypertension management. The objectives of this systematic review were to evaluate the systolic and diastolic BP reduction, and achievement of target BP, associated with self-monitoring. Methods. MEDLINE, Embase, Cochrane database of systematic reviews, database of abstracts of clinical effectiveness, the health technology assessment database, the NHS economic evaluation database, and the TRIP database were searched for studies where the intervention included self-monitoring of BP and the outcome was change in office/ambulatory BP or proportion with controlled BP. Two reviewers independently extracted data. Meta-analysis using a random effects model was combined with meta-regression to investigate heterogeneity in effect sizes. Results. A total of 25 eligible randomized controlled trials (RCTs) (27 comparisons) were identified. Office systolic BP (20 RCTs, 21 comparisons, 5,898 patients) and diastolic BP (23 RCTs, 25 comparisons, 6,038 patients) were significantly reduced in those who self-monitored compared to usual care (weighted mean difference (WMD) systolic −3.82 mmHg (95% confidence interval −5.61 to −2.03), diastolic −1.45 mmHg (−1.95 to −0.94)). Self-monitoring increased the chance of meeting office BP targets (12 RCTs, 13 comparisons, 2,260 patients, relative risk = 1.09 (1.02 to 1.16)). There was significant heterogeneity between studies for all three comparisons, which could be partially accounted for by the use of additional co-interventions. Conclusion. Self-monitoring reduces blood pressure by a small but significant amount. Meta-regression could only account for part of the observed heterogeneity